Does Protagonist Therapeutics have an economic moat?
Not clearly
Protagonist Therapeutics earns -20.6% a year on the money invested in it, a return competitors could match.
The numbers behind it
Return on invested capital, average of recent years-20.6%
Return on invested capital, latest year-21.3%
Gross margin99.5%Share of each sale left after production costs
Net margin-282.8%
How we decide
A moat shows up in the numbers as high returns that last. We call it likely when the average return on invested capital over recent years is at least 15% and the gross margin at least 40%, and possible from 10%. The numbers can't show where a moat comes from (brand, network, patents), only that one seems to exist.
More questions about Protagonist Therapeutics
Data as of Nov 13, 2026.