Best Biotechnology Stocks
Drug developers, gene therapy, mRNA platforms, diagnostics. Binary outcomes - patent + FDA risk dominate. Average ROIC negative because most pre-revenue names burn cash; the few winners compound aggressively.
Industry leader
Halozyme Therapeutics, Inc. HALO
Buffett-Fit: 79/100
What drives this industry
Biotechnology is the highest-variance industry in healthcare. Patent expirations are scheduled value destruction; FDA approvals are binary risk. The Buffett-Fit framework favours commercial-stage biotechs with sustained positive net income + clear pipeline depth - typically large-cap names rather than pre-revenue clinical-stage companies. Avoid the average; chase the winners.
Top 50 ranked by Buffett-Fit
Sorted by composite quality score - ROIC, margin stability, balance-sheet strength, growth quality. Click any ticker for the full Buffett verdict.
- 1
HALOHalozyme Therapeutics, Inc.8.1B mcap
79Q - 2
UTHRUnited Therapeutics Corporation24.1B mcap
71Q - 3
CPRXCatalyst Pharmaceuticals, Inc.3.8B mcap
69Q - 4
CORTCorcept Therapeutics Incorporated6.5B mcap
68Q - 5
ALKSAlkermes plc6.1B mcap
65Q - 6
VRTXVertex Pharmaceuticals Incorporated110.3B mcap
64Q - 7
EXELExelixis, Inc.12.6B mcap
64Q - 8
REGNRegeneron Pharmaceuticals, Inc.65.8B mcap
64Q - 9
RPRXRoyalty Pharma plc23.4B mcap
61Q - 10
HRMYHarmony Biosciences Holdings, Inc.1.7B mcap
60Q - 11
BMRNBioMarin Pharmaceutical Inc.10.5B mcap
58Q - 12
APLSApellis Pharmaceuticals, Inc.5.3B mcap
58Q - 13
GMABGenmab A/S16.5B mcap
58Q - 14
MDXGMiMedx Group, Inc.539M mcap
57Q - 15
INCYIncyte Corporation19.4B mcap
57Q - 16
NVONovo Nordisk A/S199.8B mcap
57Q - 17
CRMDCorMedix Inc.626M mcap
56Q - 18
LGNDLigand Pharmaceuticals Incorporated4.6B mcap
55Q - 19
TECHBio-Techne Corporation7.5B mcap
54Q - 20
BTXBlackRock Technology and Private Equity Term Trust1.0B mcap
54Q - 21
KRYSKrystal Biotech, Inc.8.8B mcap
51Q - 22
INVAInnoviva, Inc.1.7B mcap
51Q - 23
PTCTPTC Therapeutics, Inc.5.7B mcap
51Q - 24
ALNYAlnylam Pharmaceuticals, Inc.39.7B mcap
50Q - 25
XERSXeris Biopharma Holdings, Inc.1.1B mcap
49Q - 26
ADMAADMA Biologics, Inc.1.9B mcap
48Q - 27
XOMAXOMA Royalty Corp.522M mcap
48Q - 28
AUPHAurinia Pharmaceuticals Inc.2.0B mcap
47Q - 29
RIGLRigel Pharmaceuticals, Inc.537M mcap
47Q - 30
SLNOSoleno Therapeutics, Inc.2.8B mcap
47Q - 31
VCYTVeracyte, Inc.3.6B mcap
46Q - 32
BCRXBioCryst Pharmaceuticals, Inc.1.7B mcap
46Q - 33
LKFTGalapagos N.V. Sponsored ADR1.8B mcap
46Q - 34
JAZZJazz Pharmaceuticals plc15.0B mcap
46Q - 35
VCELVericel Corporation1.8B mcap
46Q - 36
AKTSAktis Oncology, Inc.1.1B mcap
46Q - 37
TBPHTheravance Biopharma, Inc.844M mcap
45Q - 38
TECXTectonic Therapeutic, Inc.549M mcap
44Q - 39
ARGXargenx SE49.9B mcap
44Q - 40
TGTXTG Therapeutics, Inc.6.0B mcap
42Q - 41
TLXTelix Pharmaceuticals Limited3.2B mcap
41Q - 42
WVEWave Life Sciences Ltd.1.2B mcap
40Q - 43
PHARPharming Group N.V.890M mcap
39Q - 44
LBRXLB Pharmaceuticals Inc Common Stock806M mcap
39Q - 45
FOLDAmicus Therapeutics, Inc.4.5B mcap
38Q - 46
MNKDMannKind Corporation1.0B mcap
38Q - 47
ARWRArrowhead Pharmaceuticals, Inc.10.6B mcap
37Q - 48
VTYXVentyx Biosciences, Inc.1.0B mcap
37Q - 49
NKTRNektar Therapeutics1.3B mcap
37Q - 50
SRPTSarepta Therapeutics, Inc.1.8B mcap
37Q
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Key terms in this analysis
Educational framework analysis only. Not investment advice, not a recommendation, not personalized to your situation. Always do your own research.